Clinical Research Directory

Inclusion Criteria: * Age ≥14 and ≤40 years * Amblyopia associated with strabismus and/or anisometropia * Criteria for strabismus: must meet at least one of the following: heterotropia at distance and/or near with or without spectacle correction, history of strabismus surgery, documented history of strabismus that is no longer present and felt by the investigator could have caused the amblyopia * Criteria for anisometropia: must meet at least one of the following: * ≥ 0.50 D difference in spherical equivalent between eyes * ≥ 1.50 D difference in astigmatism in any meridian between the eyes * Visual acuity measured in each eye within 7 days prior to enrollment using ETDRS protocol on a study certified visual acuity tester as follows: * Amblyopic eye visual acuity of 20/40 - 20/400 * Fellow eye visual acuity of ≥ 20/25. * Spectacle correction for measurement of enrollment visual acuity must meet the following criteria and be based on a cycloplegic refraction \< 6 months old: * Requirement for spectacle correction: * Spherical equivalent must be within 0.50 D of fully correcting anisometropia * Hyperopia ≥ 3.00 D must be corrected * Hyperopia may not be under-corrected by \>1.50 D spherical equivalent and must be symmetrically reduced in each eye * Cylinder power must be within 0.50 D of fully correcting the astigmatism * Cylinder axis must be within 6 degrees of the axis when the cylinder power is ≥ 1.00 D * Myopia of the amblyopic eye \>0.50 D spherical equivalent must be corrected * Myopia may not be under-corrected by \>0.25 D or overcorrected by \> 0.50D * Spectacles meeting the above criteria must be worn until visual acuity in amblyopic eye has not improved ≥ 1 line (5 letters) by the same testing method during 2 consecutive visual acuity measurements at least 4 weeks apart (i.e. minimum of 12 weeks spectacle correction) * Dilated eye examination within 6 months prior to enrollment * Subject must be available for at least 4 months of follow-up, have access to a phone, and be willing to be contacted * By investigator judgment, the subject is likely to comply with prescribed treatment (i.e. no prior history of poor compliance) and complete all follow up visits Exclusion Criteria: * Myopia \> -6.00 D spherical equivalent * Presence of associated findings that could cause reduced visual acuity * Nystagmus does not exclude the subject if the above visual acuity criteria are met * Treatment with topical atropine within the past 12 weeks * Previous intraocular or refractive surgery * Strabismus surgery planned within 16 weeks * Current vision therapy or orthoptics * History of seizures * Known past or present susceptibility to seizures at the discretion of the investigator * Known past or present psychological problems * Known contraindications or inability to use of a head-mounted device (over one's glasses) and/or exposure to flickering light * Current use of medication for the treatment of seizures, bipolar disorder, or migraine * Use of any medication with neuromodulatory effects, including * Medications that reduce seizure thresholds