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Esmolol Versus Dexmedetomidine for Opioid-sparing in Laparoscopic Gynecological Surgery
Sponsor: Vasiliki Samartzi
Summary
The aim of this study is to investigate and compare the effects of a continuous infusion of low-dose esmolol and dexmedetomidine versus placebo on intraoperative and postoperative opioid consumption and analgesic efficacy in patients undergoing laparoscopic hysterectomy.
Official title: The Impact of Intraoperative Esmolol and Dexmedetomidine Administration on Opioid Consumption in Laparoscopic Gynecological Procedures: A Double-blinded Randomized Study
Key Details
Gender
FEMALE
Age Range
20 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
90
Start Date
2026-07-15
Completion Date
2027-02-01
Last Updated
2026-09-29
Healthy Volunteers
No
Conditions
Interventions
Esmolol hydrochloride
In the esmolol group, patients will receive a loading dose of esmolol administered over 10 minutes in 100 mL of normal saline, followed by a continuous intraoperative esmolol infusion.
Dexmedetomidine
In the dexmedetomidine group, patients will receive a loading dose of dexmedetomidine administered over 10 minutes in 100 mL of normal saline, followed by a continuous intraoperative dexmedetomidine infusion.
Normal (0.9%) saline
In the placebo group, patients will receive a loading dose of normal saline administered over 10 minutes in 100 mL of normal saline, followed by a continuous intraoperative normal saline infusion.
Locations (1)
"Alexandra" General Hospital
Athens, Greece