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Low Level Laser Therapy With Injectable Platelet Rich Fibrin in Management of Oral Lichen Planus
Sponsor: Ain Shams University
Summary
The Injectable PRF (i-PRF) is a variant of PRF, which is a liquid blood derivative rich in leukocytes and acts as a growth factor release, with its potential anti-inflammatory role, it may alleviate the symptoms of OLP. Low Level Laser Therapy (LLLT) emits short wavelength red or infrared light between (500-1100 nm) with a low water absorption. This light can reach a depth of 3 mm to 15 mm in both soft and hard tissues, the biostimulatory effect of laser irradiation results in physiological, metabolic, and functional changes in living microorganisms. The investigators compared the clinical effectiveness of LLLT combined with (i-PRF) to the application of (i-PRF) alone and to that of topical corticosteroid regimen in symptomatic OLP and investigated therapeutic mechanism by examining treatment effect on expression of Tumor necrosis factor alpha (TNF-alpha) and Vascular endothelial growth factor (VEGF) in salivary samples from OLP patients.
Official title: Low Level Laser Therapy Combined With Injectable Platelet Rich Fibrin Versus Injectable Platelet Rich Fibrin in Management of Symptomatic Oral Lichen Planus : A Randomized Controlled Clinical Study With Biochemical Analysis
Key Details
Gender
All
Age Range
40 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
39
Start Date
2026-03-15
Completion Date
2027-05-20
Last Updated
2026-09-29
Healthy Volunteers
No
Conditions
Interventions
Injectable Platelet Rich Fibrin
Injectable Platelet Rich Fibrin (i- PRF) is a variant of PRF, a liquid blood derivative produced by using blood without anticoagulant or artificial biochemical modifications centrifuged at 700 rpm (60 g) for 3 mins in plastic tubes without any coatings.
Low Level Laser Therapy
Low Level Laser Therapy (LLLT) is a non invasive treatment, that emits short wavelength red or infrared light between (500-1100 nm) with a low water absorption. The bio stimulatory effect of laser irradiation results in physiological, metabolic, and functional changes in living microorganisms.
Triamcinolone acetonide (injection)
Topical corticosteroid
Locations (2)
Faculty of Dentistry, Ain Shams University
Cairo, Cairo Governorate, Egypt
Faculty of Dentistry, Ain Shams University
Cairo, Egypt