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Acute Musculoskeletal Responses to Blood Flow Restriction Training
Sponsor: University of Valencia
Summary
This randomized controlled trial investigated the acute musculoskeletal responses to isometric exercise with and without blood flow restriction in healthy, physically active young adults. Participants were randomly assigned to one of three groups: high-intensity isometric exercise (HI), low-intensity isometric exercise with blood flow restriction (LI-BFR), or low-intensity isometric exercise with sham blood flow restriction (LI-Sham). Ultrasound measurements of patellar tendon and vastus medialis muscle thickness were obtained before and immediately after the exercise intervention. Knee-extension maximal voluntary isometric contraction was also assessed. The study aimed to compare the acute changes in these outcomes among the three exercise conditions.
Official title: Acute Musculoskeletal Responses to Isometric Blood Flow Restriction Training of the Patellar Tendon in Healthy, Active Young Adults: A Randomized Controlled Trial
Key Details
Gender
All
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
66
Start Date
2025-10-13
Completion Date
2026-04-24
Last Updated
2026-09-29
Healthy Volunteers
Yes
Conditions
Interventions
High-Intensity Isometric Exercise
Participants performed five 30-second isometric knee-extension contractions at 70% of maximal voluntary isometric contraction (MVIC), with 60 seconds of rest between sets.
Low-Intensity Isometric Exercise With Blood Flow Restriction
Participants performed five 30-second isometric knee-extension contractions at 30% of MVIC with a pneumatic cuff inflated to 80% of the individual arterial occlusion pressure (AOP) during each contraction. The cuff was deflated during the 60-second rest periods between sets.
Low-Intensity Isometric Exercise With Sham Blood Flow Restriction
Participants performed five 30-second isometric knee-extension contractions at 30% of MVIC with a pneumatic cuff inflated to 20 mmHg during each contraction. The cuff was deflated during the 60-second rest periods between sets.
Locations (1)
University of Valencia
Valencia, Valencia, Spain