Clinical Research Directory

Inclusion Criteria: * Patients diagnosed with type 2 diabetes mellitus for more than 5 years. * Presence of painful diabetic peripheral neuropathy lasting for more than 6 months. * Presence of sensory abnormalities, burning pain, and impaired nerve conduction velocity in the lower extremities. * Medically controlled glycemic status. * Sufficient cognitive abilities with a Mini-Mental State Examination (MMSE) score greater than 24. * Fit for hyperbaric pressure therapy with a cardiac ejection fraction (CEF) equal to or greater than 50% and blood pressure equal to or less than 150/90 mmHg. Exclusion Criteria: * Peripheral neuropathy resulting from causes other than diabetes (e.g., vitamin B12 deficiency, alcohol abuse, or trauma). * Severe vascular insufficiency in the lower limbs. * Uncontrolled medical conditions such as tumors or thyroid dysfunction. * Pregnancy. * Presence of metallic implantations or cardiac pacemakers. * Severe visual, auditory, or cognitive impairment (MMSE score less than 24). * Chronic obstructive pulmonary disease (COPD) or other contraindications to hyperbaric oxygen therapy. * History of other neurological diseases (e.g., stroke or multiple sclerosis).