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Combined tDCS and Cognitive Neurorehabilitation in Post-Stroke Depression
Sponsor: Institut de Recerca Biomèdica de Lleida-Fundació Dr. Pifarré (IRBLleida)
Summary
This study evaluates a multimodal intervention pathway for affective and cognitive symptoms after ischemic stroke. Patients undergo an initial screening of depressive symptoms, cognitive function, and quality of life. Participants meeting the criteria for intervention are randomized to one of four groups: active transcranial direct current stimulation (tDCS), sham tDCS, online cognitive neurorehabilitation, or a combined intervention using active tDCS and online cognitive neurorehabilitation. Clinical outcomes include depressive symptoms, cognitive performance, and quality of life assessed longitudinally during follow-up.
Official title: Multimodal Intervention Using Transcranial Direct Current Stimulation (tDCS) and Cognitive Neurorehabilitation to Reduce Affective Symptoms in Ischemic Stroke Patients With Mild-to-moderate Sequelae
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
33
Start Date
2024-04-09
Completion Date
2026-04-17
Last Updated
2026-09-30
Healthy Volunteers
No
Conditions
Interventions
Active transcranial direct current stimulation
Active tDCS is delivered at 2 mA for 30 minutes over 14 sessions, with the anode positioned over the left dorsolateral prefrontal cortex (DLPFC) and the cathode over the right DLPFC.
Sham transcranial direct current stimulation
Sham tDCS is delivered over 14 sessions using the same electrode montage as active tDCS, without therapeutic current stimulation.
Cognitive neurorehabilitation using Guttmann NeuroPersonalTrainer
Participants complete 32 cognitive neurorehabilitation sessions of approximately 30 minutes each using Guttmann NeuroPersonalTrainer (GNPT). In the multimodal group, 14 GNPT sessions are performed concurrently with active tDCS and the remaining 18 sessions are completed at home.
Locations (1)
Hospital Universitari Arnau de Vilanova
Lleida, Lleida, Spain