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COMPLETED
NCT07848919
NA

Combined tDCS and Cognitive Neurorehabilitation in Post-Stroke Depression

Sponsor: Institut de Recerca Biomèdica de Lleida-Fundació Dr. Pifarré (IRBLleida)

View on ClinicalTrials.gov

Summary

This study evaluates a multimodal intervention pathway for affective and cognitive symptoms after ischemic stroke. Patients undergo an initial screening of depressive symptoms, cognitive function, and quality of life. Participants meeting the criteria for intervention are randomized to one of four groups: active transcranial direct current stimulation (tDCS), sham tDCS, online cognitive neurorehabilitation, or a combined intervention using active tDCS and online cognitive neurorehabilitation. Clinical outcomes include depressive symptoms, cognitive performance, and quality of life assessed longitudinally during follow-up.

Official title: Multimodal Intervention Using Transcranial Direct Current Stimulation (tDCS) and Cognitive Neurorehabilitation to Reduce Affective Symptoms in Ischemic Stroke Patients With Mild-to-moderate Sequelae

Key Details

Gender

All

Age Range

18 Years - 80 Years

Study Type

INTERVENTIONAL

Enrollment

33

Start Date

2024-04-09

Completion Date

2026-04-17

Last Updated

2026-09-30

Healthy Volunteers

No

Interventions

DEVICE

Active transcranial direct current stimulation

Active tDCS is delivered at 2 mA for 30 minutes over 14 sessions, with the anode positioned over the left dorsolateral prefrontal cortex (DLPFC) and the cathode over the right DLPFC.

DEVICE

Sham transcranial direct current stimulation

Sham tDCS is delivered over 14 sessions using the same electrode montage as active tDCS, without therapeutic current stimulation.

BEHAVIORAL

Cognitive neurorehabilitation using Guttmann NeuroPersonalTrainer

Participants complete 32 cognitive neurorehabilitation sessions of approximately 30 minutes each using Guttmann NeuroPersonalTrainer (GNPT). In the multimodal group, 14 GNPT sessions are performed concurrently with active tDCS and the remaining 18 sessions are completed at home.

Locations (1)

Hospital Universitari Arnau de Vilanova

Lleida, Lleida, Spain