Clinical Research Directory

Inclusion Criteria: * Histologically or clinically confirmed renal malignancy scheduled to receive kidney-sparing radical radiotherapy. * Baseline estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m² and serum creatinine within normal limits. * Expected survival of at least 6 months and able to comply with the study protocol and follow-up visits. * Provision of written informed consent prior to any study-related procedures. Exclusion Criteria: * Pre-existing severe renal impairment (e.g., estimated glomerular filtration rate \[eGFR\] \< 60 mL/min/1.73 m²) or history of renal failure. * Known allergy or hypersensitivity to any components of Zhixiao Tongmai Ning or other Traditional Chinese Medicine herbs. * Previous treatment with nephrotoxic agents within 4 weeks prior to enrollment, or bilateral renal involvement making kidney-sparing radiotherapy unfeasible. * Presence of severe uncontrolled systemic diseases (e.g., severe cardiovascular disease, active infection) or expected survival of less than 6 moPregnant or breastfeeding women, or patients with poor compliance who are unable to complete the required follow-up visits.nths.