Clinical Research Directory

Inclusion Criteria: * In order to participate subjects must: 1. Provide voluntary, written informed consent; 2. Be between 18 and 65 years old; 3. Understand and be willing, able and likely to comply with all study procedures and restrictions; 4. Be willing and capable of wearing a custom-made removable mandibular appliance 24 hours a day for three (3), three-week treatment periods; 5. Be in good medical and dental health with no active caries or periodontal disease; Note: subjects presenting at screening with caries may continue in the study if their carious lesions are restored prior to beginning treatment 1; and, 6. Have a salivary flow rate in the range of normal values (unstimulated whole saliva flow rate ≥ 0.2 mL/min; gum base stimulated whole saliva flow rate ≥ 0.8 mL/min); 7. Have an adequate number of teeth and space to accommodate the custom-made removable mandibular appliance, as per the study PI/study dentist's discretion. Exclusion Criteria: * No subject may: 1. Be pregnant, intending to become pregnant during the study period or breast feeding; 2. Have any medical condition that could be expected to interfere with the subject's safety during the study period (including temporomandibular disorders); 3. Be taking antibiotics during the study period, or have taken antibiotics in the two weeks prior to the beginning treatment 1; 4. Participated in another clinical study or receipt of an investigational drug within 30 days of beginning treatment 1; 5. Be taking fluoride supplements, required to use a fluoride mouthrinse or have received a professional fluoride treatment in the two weeks preceding specimen placement; or, 6. Have a history of metal allergies.