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COMPLETED
NCT07849309

Real-World Incidence of Intraocular Inflammation Following Intravitreal Treatment With Aflibercept 8 mg

Sponsor: Copenhagen University Hospital, Rigshospitalet

View on ClinicalTrials.gov

Summary

Aflibercept 8 mg is a high-concentration anti-vascular endothelial growth factor therapy developed to extend treatment intervals for retinal diseases while maintaining the efficacy and safety of aflibercept 2 mg. Phase 3 trials supported its use in neovascular age-related macular degeneration, diabetic macular edema, and retinal vein occlusion. The aim of this study was to estimate the incidence of intraocular inflammation (IOI) after intravitreal aflibercept 8 mg injections in an unselected cohort treated at a large tertiary referral center, and describe the presentation, management and outcome of the affected eyes.

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

3690

Start Date

2026-04-20

Completion Date

2026-09-14

Last Updated

2026-09-30

Healthy Volunteers

No

Interventions

DRUG

Aflibercept (Eylea)

intravitreal injection

Locations (1)

Rigshospitalet, Department of Ophthalmology

Glostrup Municipality, Denmark