Clinical Research Directory

Browse clinical research sites, groups, and studies.

Sites Groups Studies

Back to Studies

NOT YET RECRUITING

NCT07849582

Pilot Study of Individualized Neurovisual Rehabilitation Following Acquired Brain Injury

Sponsor: Charles University, Czech Republic

View on ClinicalTrials.gov

Summary

This prospective single-group pilot study will evaluate the feasibility and preliminary outcomes of an individualized neurovisual rehabilitation program for adults with visual impairment following acquired brain injury. Thirty participants will receive five individual therapist-led rehabilitation sessions together with individually prescribed self-training. The rehabilitation program will be tailored to each participant's identified visual impairment and functional difficulties. Feasibility will be evaluated through intervention uptake, attendance, completion, adherence to prescribed self-training, and completion of post-intervention assessment. Preliminary changes in self-reported visual functioning and selected objective measures of visual function will be assessed from baseline to post-intervention. Because the study has no control group, analyses of clinical outcomes will be exploratory and are not intended to provide definitive evidence of treatment efficacy.

Official title: Feasibility and Preliminary Outcomes of Individualized Neurovisual Rehabilitation Following Acquired Brain Injury: A Prospective Single-Group Pilot Study

Key Details

Gender

All

Age Range

18 Years - 85 Years

Study Type

INTERVENTIONAL

Enrollment

Start Date

2026-10-15

Completion Date

2028-03-01

Last Updated

2026-09-30

Healthy Volunteers

Conditions

Brain Injuries

Interventions

BEHAVIORAL

Individualized Neurovisual Rehabilitation

Individualized neurovisual rehabilitation will be delivered in five individual therapist-led sessions, planned approximately once weekly and completed within a maximum period of 8 weeks from the first therapist-led session. Treatment content will be selected according to each participant's identified visual impairment and functional difficulties and may include training of fixation, smooth pursuit, saccadic eye movements, vergence, gaze stabilization, visual scanning and search, visual attention, and compensatory strategies for acquired visual field loss. Participants will additionally receive individually prescribed self-training and will be instructed to perform self-training on at least 5 days per week between the first and final therapist-led rehabilitation sessions.

Inclusion Criteria: * Age 18 to 85 years. * Diagnosis of acquired brain injury, including stroke, traumatic brain injury, or brain tumor. * Enrollment between 4 weeks and 12 months after the relevant index event. The index event is defined as stroke onset for participants with stroke, date of injury for participants with traumatic brain injury, and diagnosis or treatment-related event associated with the onset of the acquired visual or neurological impairment for participants with a brain tumor. * Presence of at least one acquired visual impairment identified through standardized visual assessment and considered amenable to the planned neurovisual rehabilitation. * Sufficient cognitive ability to participate in the study assessments and rehabilitation program, defined as a Montreal Cognitive Assessment-Blind (MoCA-Blind) score greater than 10. * Sufficient ability to understand therapeutic instructions and cooperate with the study assessments and rehabilitation program. * Sufficient ability to communicate in Czech to understand therapeutic instructions and report visual difficulties. * Ability to participate regularly in the planned rehabilitation program and prescribed self-training. * Written informed consent to participate in the study. Exclusion Criteria: * Congenital visual impairment. * Pre-existing visual impairment or eye disease that was present before the acquired brain injury and could substantially interfere with the assessment or rehabilitation of visual impairment associated with the acquired brain injury. * Long-term metabolic disease with known visual complications that could substantially interfere with the assessment or rehabilitation of visual impairment associated with the acquired brain injury. * Visual impairment not considered amenable to the planned neurovisual - rehabilitation approach. Inability to complete the study assessments or participate in the rehabilitation program because of severe cognitive, communication, behavioral, or medical limitations.

Locations (1)

General University Hospital in Prague, U Nemocnice 499/2

Prague, Czechia