Clinical Research Directory

Inclusion Criteria: * right-handed, participants with schizophrenia between the ages of 18-50 years. Exclusion Criteria: * Current substance misuse * Pregnancy or breast feeding * Subjects with electrocardiographic abnormalities (particularly QTc prolongation) * Subjects with renal impairment * Subjects with hepatic impairment * Past or current neurological disorder (including stroke, brain tumor, epilepsy, Alzheimer's, Parkinson's or Huntington's disease) * Non-schizophrenia cause of cognitive impairment * Uncontrolled medical disorder that may interfere with cognition or compromise safety * Head trauma with loss of consciousness in the last year or any evidence of functional impairment due to and persisting after head trauma * Having a contraindication to MRI, including a pacemaker, defibrillator or other medical implant, other metal objects, or claustrophobia, or for having braces or other metal in the head region (likely to create an artifact on the MRI scans). * Significant suicidal ideation * Recent history of electroconvulsive therapy * Medication changes in the past six weeks