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Risk of Cervical Cancer Following Incident, Persistent and History-unknown HPV Detection
Sponsor: Karolinska Institutet
Summary
The goal of this register-based retrospective observational study is to understand the risk of cervical cancer following incident, persistent and history-unknown HPV detection by HPV genotype in healthy women participating in HPV-based cervical screening. The main questions it aims to answer are: 1. Whether an incident HPV detection with certain HPV genotypes has low risk of cervical cancer in 3 to 5 years thus does not need further clinical assessment before the next screening test? 2. How risky a persistent HPV detection is, and whether persistent detection of any high-risk HPV genotype warrant immediate clinical assessment? 3. How risky a HPV detection is, if no previous HPV test result is available? As being a register-based retrospective observational study, study subjects will not be asked to do any specific task for this study.
Official title: Risk of Cervical Cancer Following Incident, Persistent and History-unknown Human Papillomavirus (HPV) Detection by HPV Genotype
Key Details
Gender
FEMALE
Age Range
22 Years - 70 Years
Study Type
OBSERVATIONAL
Enrollment
130000
Start Date
2025-10-31
Completion Date
2026-12
Last Updated
2026-09-30
Healthy Volunteers
No
Conditions
Interventions
No Intervention: Observational Cohort
All data will be retrieved retrospectively from registry data.
Locations (1)
Centre for Cervical Cancer Elimination, Department of Clinical Science, Intervention and Technology, Karolinska Institutet
Stockholm, Sweden