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NOT YET RECRUITING
NCT07850310
PHASE1

A Clinical Trial of MK-8644 in Healthy Participants and Participants With Psoriasis (MK-8644-001)

Sponsor: Merck Sharp & Dohme LLC

View on ClinicalTrials.gov

Summary

The purpose of this trial is to learn about a trial medicine called MK-8644. This trial is the first time researchers will give MK-8644 to people. This trial will help researchers learn about the safety of MK-8644 and if participants tolerate it. Tolerate means participants will receive MK-8644 in the trial unless they need to stop it due to health problems.

Official title: A First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Ascending Doses, Food Effect, and Relative Bioavailability of MK-8644 in Healthy Japanese and Non-Japanese Participants and Multiple Doses of MK-8644 in Patients With Mild to Moderate Plaque Psoriasis

Key Details

Gender

All

Age Range

18 Years - 65 Years

Study Type

INTERVENTIONAL

Enrollment

132

Start Date

2026-10-06

Completion Date

2027-12-13

Last Updated

2026-09-30

Healthy Volunteers

Yes

Interventions

DRUG

MK-8644

Oral administration

DRUG

Placebo for MK-8644

Oral administration