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Nutritional Intervention for Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
Sponsor: Institute of Hematology & Blood Diseases Hospital, China
Summary
This is a multi-center observational study. The study aims to explore the effect of enteral nutritional support on nutritional status and clinical outcomes in patients after hematopoietic stem cell transplantation. Eligible participants will receive routine clinical care combined with nutritional intervention at each participating site. We will collect clinical and laboratory indicators to evaluate changes in nutrition-related indexes. No extra invasive procedures will be performed for research purposes.
Official title: Effect of Nutritional Intervention on Disease Outcomes in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
160
Start Date
2026-10-12
Completion Date
2030-10-30
Last Updated
2026-09-30
Healthy Volunteers
No
Interventions
Enteral Nutritional Suspension (TP-MCT)
500 mL per day of enteral nutritional suspension (TP-MCT), whole-protein formula, 1 kcal/mL, administered orally in addition to routine dietary guidance. Dose titrated from 20-50 mL initial volume to target dose according to gastrointestinal tolerance. Provided by Nutricia Pharmaceutical (Wuxi) Co., Ltd.
Routine nutritional guidance
Standard clinical dietary guidance without oral nutritional supplement. Parenteral nutrition will be supplemented to meet target energy requirements when oral intake is insufficient.
Biospecimen-Stool Sample Collection
Collection of 40 g first-voided fresh stool samples at seven predefined study time-points for gut microbiota analysis. Specimens are transported under 4 °C cold-chain conditions and stored long-term at -80 °C for laboratory testing.
Non-contact Millimeter-Wave Radar Sleep-Breathing Monitoring
24-hour non-contact sleep-breathing monitoring is performed via millimeter-wave radar device on the day of conditioning initiation and on the day of stem-cell infusion. No wearable sensors are required for participants to collect sleep-respiratory parameters.
Locations (3)
The First Hospital of Jilin University
Changchun, Jilin, China
Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College
Tianjin, Tianjin Municipality, China
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, Zhejiang, China