Clinical Research Directory

Inclusion Criteria: * Age ranges from 6 - 8 years. * Children free of any systemic disease or special health care need (ASA I). * Positive or definitely positive behavior during preoperative assessments * according to the Frankl Rating Scale (score 3 or 4). * Patients whose parents will give their written consent to participate. * MIH-affected PFMs with Treatment Need index (TNI) 4c). * Schiff Cold Air Sensitivity Scale (SCASS) scores 2 and 3. * Restorable MIH-affected PFMs associated with signs and symptoms of irreversible pulpitis * Spontaneous, unprovoked pain * Lingering pain after thermal stimulus. * Exacerbation by postural changes. * Referred pain. * Nocturnal pain. * Haemostasis achieved within 10 minutes * Negative response to percussion and palpation * Restorable non-MIH-affected PFMs associated with signs and symptoms of irreversible pulpitis. Exclusion Criteria: * Medically compromised patients. * Allergies to local anesthesia. * Intolerance to NSAIDs. * Patients with Frankl scores 1 and 2. * Patients who took analgesics or antibiotics in the last 12 hours. * Non-restorable permanent first molars. * Non-vital permanent first molars (negative response to pulp testing). * Tooth mobility with grades 2 and 3. * pocket depth greater than 5 mm. * Radiographic evidence of vertical root fracture, perforation, and/or peri-apical radiolucency. * Widening of periodontal ligament. * Pain on percussion. * Uncontrolled puplpal haemorrhage lasting more than 10 minutes * Degenerating pulp