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Torvutatug Samrotecan Plus Bevacizumab as First-line Maintenance in Homologous Recombination Deficiency (HRD) Negative Advanced Epithelial Ovarian Cancer
Sponsor: AstraZeneca
Summary
This study will evaluate the efficacy, safety and tolerability of Torvutatug samrotecan (torvu-sam) in combination with bevacizumab compared with bevacizumab monotherapy as first line maintenance treatment in patients with Homologous Recombination Deficient (HRD) negative advanced ovarian cancer.
Official title: A Randomised, Open-label, Phase III Study of Torvutatug Samrotecan in Combination With Bevacizumab Versus Bevacizumab Monotherapy as First-line Maintenance Treatment in Participants With Homologous Recombination Deficiency (HRD) Negative Advanced Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (TREVI-OC-02)
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
950
Start Date
2026-09-16
Completion Date
2033-08-17
Last Updated
2026-10-01
Healthy Volunteers
No
Conditions
Interventions
Torvutatug samrotecan
Antibody drug conjugate
Bevacizumab
Monoclonal antibody inhibitor of Vascular Endothelial Growth Factor
Locations (186)
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Tampa, Florida, United States
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Baltimore, Maryland, United States
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Billings, Montana, United States
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Cleveland, Ohio, United States
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Buenos Aires, Argentina
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Buenos Aires, Argentina
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Capital Federal, Argentina
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Ciudad de Buenos Aires, Argentina
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Ciudad de Buenos Aires, Argentina
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Córdoba, Argentina
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Córdoba, Argentina
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Córdoba, Argentina
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Rosario, Argentina
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Salta, Argentina
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Santa Fe, Argentina
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Viedma, Argentina
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Auchenflower, Australia
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Benowa, Australia
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Hobart, Australia
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Kingswood, Australia
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Nedlands, Australia
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Port Macquarie, Australia
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Randwick, Australia
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Richmond, Australia
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Toorak Gardens, Australia
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Wollongong, Australia
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Fortaleza, Brazil
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Itajaí, Brazil
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Jaú, Brazil
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Natal, Brazil
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Porto Alegre, Brazil
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Rio de Janeiro, Brazil
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Salvador, Brazil
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São Paulo, Brazil
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São Paulo, Brazil
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São Paulo, Brazil
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Dobrich, Bulgaria
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Plovdiv, Bulgaria
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Shumen, Bulgaria
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Sofia, Bulgaria
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Sofia, Bulgaria
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Sofia, Bulgaria
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Toronto, Ontario, Canada
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Montreal, Quebec, Canada
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Santiago, Chile
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Santiago, Chile
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Temuco, Chile
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Viña del Mar, Chile
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Beijing, China
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Beijing, China
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Beijing, China
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Beijing, China
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Binzhou Shi, China
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Changchun, China
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Changsha, China
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Chengdu, China
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Chongqing, China
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Fuzhou, China
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Guangzhou, China
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Haikou, China
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Hangzhou, China
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Hangzhou, China
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Hangzhou, China
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Hefei, China
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Huangpu District, China
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Jinan, China
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Jinan, China
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Linyi, China
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Luzhou, China
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Nanchang, China
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Nanjing, China
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Nanjing, China
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Neijiang, China
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Shanghai, China
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Shanghai, China
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Shenzhen, China
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Shijiazhuang, China
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Suzhou, China
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Taiyuan, China
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Weifang, China
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Wenzhou, China
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Wuhan, China
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Xinxiang, China
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Xuzhou, China
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Bogotá, Colombia
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Bogotá, Colombia
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Medellín, Colombia
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Pasto, Colombia
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Berlin, Germany
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Bonn, Germany
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Hanover, Germany
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Wiesbaden, Germany
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Athens, Greece
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Pátrai, Greece
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Ansārinagar, India
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Bhubaneswar, India
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Hyderabad, India
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Mumbai, India
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Mumbai, India
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Nagpur, India
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Nashik, India
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New Delhi, India
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Pune, India
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Thiruvananthapuram, India
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Hadera, Israel
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Haifa, Israel
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Haifa, Israel
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Holon, Israel
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Jerusalem, Israel
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Kfar Saba, Israel
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Nahariya, Israel
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Tel Aviv, Israel
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Florence, Italy
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Genova, Italy
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Fukushima, Japan
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Ginowan-shi, Japan
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Hidaka-shi, Japan
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Isehara-shi, Japan
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Kashiwa-shi, Japan
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Kawasaki-shi, Japan
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Kobe, Japan
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Kōtoku, Japan
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Kurume-shi, Japan
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Kyoto, Japan
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Minatoku, Japan
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Nagoya, Japan
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Nagoya, Japan
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Niigata, Japan
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Osaka, Japan
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Osaka, Japan
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Ota-shi, Japan
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Sagamihara-shi, Japan
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Sapporo, Japan
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Sapporo, Japan
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Sendai, Japan
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Shinjuku-ku, Japan
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Shiwa-gun, Japan
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Suita, Japan
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Sunto-gun, Japan
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Toon-Shi, Japan
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Tsu, Japan
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Yokohama, Japan
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Yokohama, Japan
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Kuala Lumpur, Malaysia
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Kuala Selangor, Malaysia
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Kuala Selangor, Malaysia
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Petaling Jaya, Malaysia
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Arequipa, Peru
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Lima, Peru
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Lima, Peru
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Lima, Peru
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Wanchac, Peru
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Cebu, Philippines
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City of Muntinlupa, Philippines
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Quezon, Philippines
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Trenčín, Slovakia
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Ljubljana, Slovenia
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Busan, South Korea
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Daegu, South Korea
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Goyang-si, South Korea
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Gyeonggi-do, South Korea
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Seongnam-si, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Yangsan, South Korea
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Barcelona, Spain
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Barcelona, Spain
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Kaohsiung City, Taiwan
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Kaohsiung City, Taiwan
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New Taipei City, Taiwan
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Taichung, Taiwan
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Taichung, Taiwan
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Tainan, Taiwan
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Tainan, Taiwan
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Taipei, Taiwan
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Taipei, Taiwan
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Taipei, Taiwan
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Taipei, Taiwan
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Taoyuan, Taiwan
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Bangkok, Thailand
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Bangkok, Thailand
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Bangkok, Thailand