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A Study to Evaluate the Immune Response and Safety of a Vaccine Against Influenza in Adults 18-64 Years of Age
Sponsor: GlaxoSmithKline
Summary
This clinical trial will study an investigational seasonal influenza vaccine in adults 18 to 64 years of age. The vaccine is based on messenger ribonucleic acid, also called mRNA. The main goals of the study are to learn how well the vaccine helps the body make an immune response against influenza and what medical problems participants may have after vaccination. Researchers will also compare immune responses in adults 18 to 64 years of age from this study, with immune responses in adults 65 years of age and older from another study. Participants will receive 1 injection into the upper arm muscle and will be followed for about 6 months.
Official title: A Phase 3 Randomized, Observer-Blind, Controlled Study to Evaluate the Immunogenicity, Reactogenicity and Safety of an mRNA-based Seasonal Influenza Vaccine, in Adults 18-64 Years of Age
Key Details
Gender
All
Age Range
18 Years - 64 Years
Study Type
INTERVENTIONAL
Enrollment
3000
Start Date
2026-10-01
Completion Date
2027-07-09
Last Updated
2026-10-09
Healthy Volunteers
Yes
Conditions
Interventions
mRNA Seasonal Flu vaccine
One dose of the mRNA Flu vaccine received intramuscularly.
Comparator 1
One dose of the comparator vaccine received intramuscularly.
Comparator 2
One dose of the comparator vaccine received intramuscularly.
Locations (12)
GSK Investigational Site
Glendale, Arizona, United States
GSK Investigational Site
Tucson, Arizona, United States
GSK Investigational Site
San Diego, California, United States
GSK Investigational Site
Miami, Florida, United States
GSK Investigational Site
Miami Lakes, Florida, United States
GSK Investigational Site
Meridian, Idaho, United States
GSK Investigational Site
Valparaiso, Indiana, United States
GSK Investigational Site
Lenexa, Kansas, United States
GSK Investigational Site
Hartsdale, New York, United States
GSK Investigational Site
Spartanburg, South Carolina, United States
GSK Investigational Site
DeSoto, Texas, United States
GSK Investigational Site
Fort Worth, Texas, United States