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Neuromuscular Electrical Stimulation in Peripheral Arterial Disease
Sponsor: Halic University
Summary
This randomized controlled trial investigated the effects of neuromuscular electrical stimulation (NMES), in addition to optimal medical therapy (OMT), on walking capacity, pain, fatigue, and quality of life in individuals with intermittent claudication due to peripheral arterial disease (PAD). A total of 48 participants were randomly allocated to either the NMES or control group. Participants in the NMES group received NMES for 40 minutes per session, three times per week, for six weeks, in addition to OMT, whereas the control group received OMT alone. Outcome measures included walking capacity, pain, fatigue, disease-specific and generic quality of life, and ankle-brachial index (ABI). Assessments were performed at baseline and after the 6-week intervention.
Official title: The Effects of Neuromuscular Electrical Stimulation on Walking Capacity, Pain, Fatigue, and Quality of Life in Individuals With Intermittent Claudication Due to Peripheral Arterial Disease
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
48
Start Date
2025-10-01
Completion Date
2026-01-10
Last Updated
2026-10-01
Healthy Volunteers
No
Conditions
Interventions
NMES
NMES was applied bilaterally to the tibialis anterior and gastrocnemius muscles using a four-channel portable stimulator. Stimulation was delivered with a symmetrical biphasic waveform at 35-50 Hz, a pulse duration of 300-400 μs, and a duty cycle of 10 seconds on and 20 seconds off. Each session lasted 40 minutes and was administered three times per week for six weeks (18 sessions) under physiotherapist supervision. Stimulation intensity was individually adjusted to produce visible, rhythmic muscle contractions without voluntary muscle activation.
OMT
Participants received OMT according to current PAD guidelines and the recommendations of their treating physicians.
Locations (1)
Haliç University
Istanbul, Eyüpsultan, Turkey (Türkiye)