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iTBS Versus Standard 10 Hz rTMS for Treatment-Resistant Depression (TRD)
Sponsor: Kafrelsheikh University
Summary
This randomised, parallel-group, non-inferiority trial compared intermittent theta burst stimulation (iTBS, 3-minute sessions) with standard 10 Hz repetitive transcranial magnetic stimulation (rTMS, 37-minute sessions) applied to the left dorsolateral prefrontal cortex (DLPFC) in adults with treatment-resistant depression (TRD). Participants received 20 sessions over 4 weeks. The primary aim was to determine whether iTBS is non-inferior to standard rTMS in reducing depressive symptoms (HDRS-17) at Week 4, and to compare patient-reported treatment experience and acceptability between protocols.
Official title: A Randomised Controlled Non-Inferiority Study Comparing Efficacy of Intermittent Theta Burst Stimulation Versus Standard 10HZ Repetitive Transcranial Magnetic Stimulation In Treatment-Resistant Depression Patients
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
182
Start Date
2026-06-30
Completion Date
2027-04-30
Last Updated
2026-10-01
Healthy Volunteers
No
Conditions
Interventions
iTBS
Device: Intermittent Theta Burst Stimulation (iTBS), delivered via Magnetism rapid TMS machine (UK) with figure-8 coil
rTMS
Device: Standard 10 Hz Repetitive Transcranial Magnetic Stimulation (rTMS), delivered via Magnetism rapid TMS machine (UK) with figure-8 coil
Locations (1)
: Kafr-Elsheikh Outpatient Psychiatric Clinic, Egypt; Menoufia Outpatient Psychiatric Clinic, Egypt
Kafr ash Shaykh, Egypt