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Investigating the Effect of the Non-nutritive Sweetener Sucralose in Inflammatory Bowel Disease
Sponsor: Case Western Reserve University
Summary
This study will focus on the commonly used non-nutritive sweetener (NNS) sucralose (2 sachets/day resulting in daily dose: sucralose 2.5mg/kg) and its role in changing the gut microbiota in humans with Inflammatory Bowel Disease (IBD), compared to healthy non-IBD individuals. We will focus on studying IBD patients affected with Crohn's Disease (CD) as a proof of principle that could be tested later in other IBD subtypes (ulcerative colitis or others specific surgical conditions).
Official title: The Effect of Non-Nutritive Food Sweeteners in Inflammatory Bowel Disease
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2024-04-18
Completion Date
2027-06
Last Updated
2026-10-01
Healthy Volunteers
Yes
Interventions
Sucralose (non-nutritive sweetener)
Participants will consume 2 sachets/day during the exposure period resulting in the following daily dose: sucralose 2.5mg/kg. This dose is below the acceptable daily intakes (ADI) of 5mg/kg.
Locations (3)
UH Minoff Health Center
Chagrin Falls, Ohio, United States
University Hospitals Cleveland Medical Center
Cleveland, Ohio, United States
UH Westlake Health Center
Westlake, Ohio, United States