Clinical Research Directory
Browse clinical research sites, groups, and studies.
Controlled Ventilation During Anesthetic Emergence
Sponsor: King Abdulaziz Medical City
Summary
Absolutely - for a \*\*ClinicalTrials.gov-style Brief Summary\*\*, I'd keep it simple and patient-friendly like your example: The goal of this clinical trial is to learn whether maintaining controlled mechanical ventilation during emergence from general anesthesia can improve the quality and safety of recovery compared with conventional supported weaning in adults undergoing surgery with a breathing tube. The main questions it aims to answer are: * Does controlled mechanical ventilation during emergence reduce coughing and the duration of coughing before removal of the breathing tube? * Does it reduce agitation during emergence from anesthesia? * Does it reduce the need for breathing support, such as continuous positive airway pressure (CPAP), after removal of the breathing tube? * Are there differences in oxygen levels, blood pressure, heart rate, airway complications, or the time required for removal of the breathing tube? Researchers will compare controlled mechanical ventilation with conventional supported weaning during emergence from general anesthesia. Participants will: * Receive general anesthesia with a breathing tube for their planned surgery * Be assigned to either controlled mechanical ventilation or conventional supported weaning during emergence from anesthesia * Have their coughing, agitation, oxygen levels, blood pressure, heart rate, and airway-related events monitored during emergence * Have the time to removal of the breathing tube and any need for additional breathing support recorded This version is deliberately written in \*\*plain language rather than manuscript language\*\*, which is much closer to what ClinicalTrials.gov expects for the brief summary.
Official title: Controlled Mechanical Ventilation During Emergence From General Anesthesia Versus Conventional Supported Weaning for Awake Extubation: a Prospective, Randomized, Open-label, Parallel-group Clinical Trial
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
76
Start Date
2024-08-17
Completion Date
2025-03-16
Last Updated
2026-10-01
Healthy Volunteers
Yes
Interventions
Controlled/Full-Support Mechanical Ventilation During Emergence
Participants assigned to the intervention arm were maintained on controlled or full-support mechanical ventilation during emergence from general anesthesia rather than transitioning to conventional supported or spontaneous weaning. Ventilation modes included pressure-controlled ventilation (PCV), pressure-controlled ventilation-volume guaranteed (PCV-VG), synchronized intermittent mandatory ventilation (SIMV), and volume-controlled ventilation (VCV), with a target respiratory rate of 12 to 16 breaths per minute. Fresh gas flow was maintained at 10 to 15 L/min until end-tidal sevoflurane reached approximately 0.2 percent. Extubation was performed when the train-of-four ratio was at least 0.9, BIS or Entropy was 80 to 100, the participant opened the eyes in response to being called by name, and the attending anesthesiologist judged awake extubation to be appropriate.
Locations (1)
king Abdulaziz Medical City
Riyadh, Saudi Arabia