Clinical Research Directory

Inclusion Criteria: * 65 years old ≤ age ≤ 80 years old; * undergo sedated transperineal prostate biopsy; * 18.5kg/m2 ≤ BMI\<30kg/m2 * ASA ≤ III; * voluntarily participate in the research and sign the informed consent form. Exclusion Criteria: * expected difficult airway; * hypertension (with a systolic blood pressure of ≥ 180 mmHg and/or a diastolic blood pressure of ≥ 100 mmHg), or with a systolic blood pressure of ≤ 90 mmHg; * baseline SpO2 \< 93%, or RR \< 10 b/m or more than 24 b/m, or a clear diagnosis of obstructive sleep apnea syndrome (OSAS); * diagnosed with heart disease (heart failure, angina, myocardial infarction, arrhythmia, etc.); * diagnosed with lung diseases (asthma, bronchitis, COPD, pulmonary bullae, pulmonary embolism, pulmonary oedema, etc.); * hepatic dysfunction (aspartate aminotransferase and/or alanine aminotransferase ≥ 2.5 times the upper limit of normal value, total bilirubin ≥ 1.5 times the upper limit of normal value); * renal insufficiency (creatinine level ≥ 1.5 times the upper limit of the normal range); * cognitive or mental disorders; * history of drug and/or alcohol abuse within 2 years before initiating the screening period; average daily alcohol consumption of \>2 units of alcohol (1 unit = 360 mL beer or 45 mL liquor with 40% alcohol content or 150 mL grapes liquor); * allergies or contraindication to benzodiazepines, opioids, propofol; * use of benzodiazepines, propofol and opioid drugs within the past three months; * participated in other drug clinical trials in the past 3 months; * investigator's judgment as an unsuitable participant.