Clinical Research Directory

Inclusion Criteria: * Age 18 years or older * Confirmed diagnosis of ulcerative colitis or Crohn's disease * Objective evidence of active disease at baseline * Planned initiation or escalation of IBD treatment * Baseline CBC with differential, CRP, and serum albumin available * Planned follow-up assessment at approximately 12-16 weeks * Planned follow-up colonoscopy with mucosal biopsies at approximately 12-16 weeks * Written informed consent Exclusion Criteria: * Active infection * Recent major surgery * Malignancy * Hematological malignancy or disorder substantially altering leukocyte or platelet counts * Significant uncontrolled liver disease * Severe renal disease expected to substantially affect inflammatory markers * Recent blood transfusion * Pregnancy * Concomitant autoimmune inflammatory disease * Systemic corticosteroids used for another indication * Acute severe infection around the time of blood sampling * Inadequate follow-up or missing essential data