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NOT YET RECRUITING
NCT07855510
PHASE1

A Clinical Trial of V175 and V175A in Healthy Adults

Sponsor: Merck Sharp & Dohme LLC

View on ClinicalTrials.gov

Summary

Researchers are looking for new vaccines to prevent lower respiratory tract infections. A lower respiratory tract infection is an infection in the lower part of the airways and/or the lungs. Respiratory syncytial virus (RSV), amongst other respiratory viruses, can cause these infections. This trial will look at the RSV multivalent vaccines V175 and V175A in healthy participants. The goal of the trial is to learn about the safety of V175 and V175A and if participants tolerate them.

Official title: A Phase 1, Randomized, Double-Blind, Comparator-Controlled, Dose Escalation Trial to Evaluate the Safety, Tolerability, and Immunogenicity of V175 and V175A in Healthy Adults

Key Details

Gender

All

Age Range

18 Years - 84 Years

Study Type

INTERVENTIONAL

Enrollment

564

Start Date

2026-10-27

Completion Date

2028-08-08

Last Updated

2026-10-02

Healthy Volunteers

Yes

Interventions

BIOLOGICAL

V175

Intramuscular administration

BIOLOGICAL

V175A

Intramuscular administration

BIOLOGICAL

Control Vaccine

Intramuscular administration

OTHER

Placebo

Intramuscular administration