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Shrimp Sensitization and Allergy Among Patients With Edible Insect Allergy
Sponsor: Mahidol University
Summary
This study aims to determine the prevalence of shrimp sensitization and clinical shrimp allergy among patients aged ≥7 years with confirmed allergy to edible insects, including silkworm, bamboo worm, and palm weevil. Participants undergo skin prick testing, specific IgE testing, ALEX2, immunoblot analysis, and risk-based oral food challenges to assess clinical cross-reactivity between edible insects and white shrimp and to help avoid unnecessary shrimp restriction.
Key Details
Gender
All
Age Range
7 Years - Any
Study Type
INTERVENTIONAL
Enrollment
19
Start Date
2026-08-30
Completion Date
2027-06
Last Updated
2026-10-08
Healthy Volunteers
Yes
Interventions
Edible Insect Oral Food Challenge
Participants with suspected edible insect allergy who do not have a history of anaphylaxis or a previous positive oral food challenge will undergo an oral food challenge to the implicated edible insect (silkworm, bamboo worm, or palm weevil). The challenge will be performed using a graded protocol under medical supervision. Participants will be observed for at least 120 minutes after completion of the challenge.
White Shrimp Oral Food Challenge
Participants with confirmed edible insect allergy will undergo a risk-based oral food challenge to white shrimp when clinically appropriate. Participants with previous tolerance will receive a single-step challenge with 100% of the age-appropriate serving, whereas those who have never consumed white shrimp or have a history of mild reactions will undergo a 4-step graded challenge (1/12, 1/6, 1/4, and 1/2 of the total serving). Participants with a history of white shrimp anaphylaxis or a white shrimp SPT wheal \>22.5 mm will not undergo the challenge. Participants will be observed for at least 120 minutes after the challenge
Locations (1)
Siriraj hospital
Bangkok, Bangkoknoi, Thailand