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Remifentanil Versus Remifentanil-Lidocaine for Tracheal Extubation After Thyroidectomy
Sponsor: Pamukkale University
Summary
This randomized, double-blind clinical trial will compare the effects of remifentanil alone and remifentanil combined with intravenous lidocaine on the quality of tracheal extubation in adult patients undergoing elective thyroidectomy under general anesthesia. A total of 60 patients will be randomly assigned to two groups. Both groups will receive remifentanil during emergence from anesthesia, while one group will additionally receive intravenous lidocaine before extubation. The primary outcome will be the incidence of coughing during tracheal extubation. Secondary outcomes will include cough severity, hemodynamic responses, oxygen saturation, airway-related adverse events, postoperative sore throat, hoarseness, postoperative nausea and vomiting, sedation level, and recovery and extubation times.
Official title: Comparison of the Effects of Remifentanil and Remifentanil-Lidocaine Combination on Tracheal Extubation Quality in Patients Undergoing Thyroidectomy
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2026-10
Completion Date
2026-11
Last Updated
2026-10-05
Healthy Volunteers
No
Conditions
Interventions
remifentanil
Remifentanil will be administered intravenously at 0.02-0.06 µg/kg/min during anesthesia and titrated according to the study protocol during the emergence period.
Lidocaine %2 ampoule
Lidocaine 1.5 mg/kg will be administered intravenously as a slow bolus over 1-2 minutes during surgical dressing before tracheal extubation.
Locations (1)
Pamukkale University Hospitals
Denizli, Turkey (Türkiye)