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NOT YET RECRUITING
NCT07857473
PHASE2

A Study to Investigate the Safety and Efficacy of TE-8105 in Overweight or Obesity Participants

Sponsor: Immunwork, Inc.

View on ClinicalTrials.gov

Summary

This is a Phase 2b, randomized, double-blind, placebo-controlled, multiple ascending dose study designed to evaluate the safety, tolerability, pharmacokinetics (PK), and efficacy of TE-8105 in adults with overweight or obesity, with or without weight-related health conditions. Participants in this study will receive subcutaneous (under the skin) injections of either TE-8105 or placebo for 25 weeks. The total study duration, including screening and follow-up visits, is approximately 8 months.

Official title: A Randomized, Double-Blind, Placebo-Controlled Phase 2b Study to Investigate the Safety and Efficacy of TE-8105 Administered Subcutaneously in Participants With Overweight or Obesity

Key Details

Gender

All

Age Range

18 Years - 65 Years

Study Type

INTERVENTIONAL

Enrollment

204

Start Date

2026-10

Completion Date

2028-02

Last Updated

2026-10-05

Healthy Volunteers

No

Interventions

DRUG

TE-8105 MAD Cohort 1

Administered via SC injection.

DRUG

TE-8105 MAD Cohort 2

Administered via SC injection.

DRUG

TE-8105 MAD Cohort 3

Administered via SC injection.

DRUG

Placebo

Administered via SC injection.

Locations (2)

Canopy Clinical Inner West

Leichhardt, New South Wales, Australia

Canopy Clinical Western Sydney

Penrith, New South Wales, Australia