Clinical Research Directory

Inclusion Criteria: * patients with knee osteoarthritis aged 18 to 75 years * Kellgren-Lawrence osteoarthritis grade 1-3 * onset of knee symptoms (pain) at least 6 months prior * ability to follow study instructions and attend follow-up visits * signed informed consent for participation in the study Exclusion Criteria: * patients with malignancies, systemic inflammatory diseases (e.g., rheumatoid arthritis, psoriatic arthritis), or other systemic diseases that may result in knee pain * patients with a body mass index (BMI) greater than 30 or diabetes * patients with 6 or more painful body points, distributed above and below the waist, on both sides of the body, and in the axillary region * patients with depression (according to the CESD-R questionnaire) * patients with Grade 4 knee osteoarthritis according to the Kellgren-Lawrence classification * patients with post-traumatic osteoarthritis * patients with rheumatoid arthritis * patients with a history of knee surgery * patients with a mechanical axis deviation (valgus/varus) of the lower extremities greater than 5° * patients with knee instability * patients with damage to the meniscus or other knee structures as the primary cause of pain and other symptoms * patients with a history of knee injury within the last 3 months * patients with other musculoskeletal problems/diseases that would prevent clinical evaluation of the effects of PRP treatment * patients treated with intra-articular knee injections (corticosteroids, hyaluronic acid, platelet-rich plasma, etc.) within the last 3 months * patients with joint chondromatosis or villonodular synovitis knee * knee joint infection * pregnant patients or patients planning pregnancy during the study period * history of chemotherapy or radiotherapy to the limb * patients with mental illness (where cooperation during the project cannot be expected) * patients determined unable to attend follow-up appointments