Clinical Research Directory

Inclusion Criteria: * Screening visit SBP from 110 to 139 mmHg and DBP \<90 mmHg based on the average of three consecutive measurements in a single visit via AOBPM * Body mass index between 18.5 and 35 kg/m2, inclusive * Untreated serum LDL-C ≥100 mg/dL (≥2.6 mmol/L). * Absence of evidence or diagnoses of acute or chronic disease following a detailed medical and surgical history * Female participants who are of childbearing potential must be willing to use two highly effective methods of contraception * Able to participate, and willing to give written informed consent and to comply with the study restrictions\[S Exclusion Criteria: * Any active or chronic disease * Confirmed SBP ≥140 mmHg or DBP ≥90 mmHg at Screening * History of orthostatic hypotension, postural orthostatic tachycardic syndrome, unexplained dizziness, fatigue, pre-syncope, or syncope. * Resting pulse rate \<50 or \>100 beats/min. * Age ≥ 40 years and having a 10-year risk of ASCVD ≥ 7.5% based on the ASCVD Risk Estimator Plus (PREVENT™ mode) from the American College of Cardiology * Participants with any risk factors or family history for QT or Fridericia-corrected QT interval (QTcF) prolongation or ECG abnormalities or any abnormality in the ECG that, in the opinion of the investigator, increases the risk of participating in the study will be excluded. Screening, Day 1, or pre-dose QTcF \< 300 msec or \> 450 msec for males and \> 470 msec for females. * Clinically significant abnormalities on physical examination, vital signs, or laboratory test results during Screening or prior to admission to the study unit. * Fasting triglyceride level ≥ 400 mg/dL (≥ 4.52 mmol/L). * Estimated glomerular filtration rate (eGFR) \< 60 mL/min. * Alanine aminotransferase (ALT) and/or total bilirubin \> 1.5 × Upper Limits of Normal (ULN). Aspartate aminotransferase (AST), alkaline phosphatase (ALP), or gamma glutamyl transferase (GGT) \> 2 × ULN. International normalized ratio (INR) above the upper bound of the normal reference range (as per the local laboratory reference range) at Screening.