Clinical Research Directory

Inclusion Criteria: * Diagnosis of mild traumatic brain injury (TBI), as defined by the 2023 American Congress of Rehabilitation Medicine (ACRM) criteria. * Enrollment within 24 hours of injury. * Glasgow Coma Scale (GCS) score of 15 at emergency department (ED) enrollment. * Consent to study procedures, including: * Blood collection for biomarker measurement, including glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase L1 (UCH-L1). * Continuous use of a health-monitoring device for 3 months. * Follow-up assessments by telephone at 14 days and 90 days. * Completion of a daily symptom inventory via WHOOP/smartphone. Exclusion Criteria: * Pre-existing neurological disability or pre-injury condition that would have resulted in a Glasgow Outcome Scale-Extended (GOS-E) score \<8 if assessed before the injury. * High risk of loss to follow-up, including patients without a reliable phone, those experiencing homelessness, those who are incarcerated, or those who are wards of the state. * Pregnancy at the time of enrollment. * Inability to speak English or Spanish, which would prevent completion of the required assessments.