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VICIA FABA PEPTIDES AND RESISTANCE TRAINING IN THE ELDERLY
Sponsor: Universidade Cesumar (UNICESUMAR)
Summary
This randomized, double-blind, placebo-controlled clinical trial aims to investigate the effects of supplementation with peptides derived from Vicia faba L. combined with supervised resistance training in physically active and inactive older adults. Approximately 100 adults aged 60 years or older will be enrolled. Participants will first be classified as physically active or inactive according to their habitual physical activity level and will then be randomly assigned to receive either Vicia faba L.-derived peptides (2.5 g/day) or placebo. All participants will complete the same supervised resistance training program three times per week for four weeks and will receive nutritional monitoring. Assessments will be performed before and after the intervention to investigate changes in muscle strength and power, body composition, functional mobility, postural balance, physical function, frailty, mental health, quality of life, and cognitive performance. The study will also examine whether habitual physical activity level influences the responses to the combined supplementation and resistance training intervention.
Official title: INVESTIGATION OF THE (POTENTIAL) THERAPEUTIC EFFECTS OF VICIA FABA L. PEPTIDES COMBINED WITH RESISTANCE TRAINING ON THE STRENGTH, FUNCTION, AND BODY COMPOSITION OF PHYSICALLY ACTIVE AND INACTIVE OLDER ADULTS: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED CLINICAL STUDY
Key Details
Gender
All
Age Range
60 Years - Any
Study Type
INTERVENTIONAL
Enrollment
77
Start Date
2026-11
Completion Date
2027-01
Last Updated
2026-10-05
Healthy Volunteers
Yes
Conditions
Interventions
Vicia faba L.-derived peptides
Participants assigned to the experimental intervention will receive 2.5 g/day of Vicia faba L.-derived peptides for four weeks. The supplement will be administered once daily as a powder using a measuring scoop containing the prescribed dose and diluted in 300 mL of drinking water. Participants will consume the supplement at home every day, including weekends. Containers will be returned at the end of the intervention to assess adherence.
Placebo
Participants assigned to the placebo intervention will receive silicified microcrystalline cellulose once daily for four weeks. The placebo will be administered as a powder diluted in 300 mL of drinking water and will be standardized to match the mode of presentation and administration of the experimental supplement. Participants will consume the placebo at home every day, including weekends. Containers will be returned at the end of the intervention to assess adherence.
Supervised Resistance Training
All participants will complete a supervised resistance training program for four weeks, with three sessions per week performed on non-consecutive days. The program will target the major muscle groups of the upper and lower limbs using resistance-training equipment, free weights, and other available implements. Exercise prescription will be individualized according to each participant's functional capacity, previous experience, and clinical limitations. Training loads will be progressively adjusted throughout the intervention according to individual progress and exercise tolerance.
Locations (1)
UniCesumar - Centro Universitário Cesumar
Maringá, Paraná, Brazil