Clinical Research Directory

Inclusion Criteria: Age 18 to 35 years Type 1 diabetes diagnosed more than 1 year before screening HbA1c 10.0% or less within the last 3 months (may be measured at screening) Body mass index 18 to 29.9 kg/m\^2 Stable insulin delivery method for the past 30 days Ability to read all device instructions and insulin pump settings Estimated glomerular filtration rate at least 60 mL/min/1.73 m\^2 within the last 3 months (may be measured at screening) Use of an insulin pump or insulin delivery by multiple daily injections Attendance at 3 or more diabetes care visits over the past 12 months Exclusion Criteria: Diabetes-related hospitalization, including for diabetic ketoacidosis or severe hypoglycemia, within 12 months of screening Poorly controlled hypertension, defined as systolic blood pressure at least 140 mmHg or diastolic blood pressure at least 90 mmHg Taking diabetes medications other than insulin Structured exercise more than 150 minutes per week for the last 3 months Pregnant, lactating, or planning to become pregnant within the study period Unstable weight, defined as more than 5% change in the last 3 months Significant organ system dysfunction, such as severe pulmonary, renal, hepatic, or cardiovascular disease Diagnosed anemia or known hemoglobin less than 10 g/dL Diagnosed neuropathic or psychiatric illness Active nicotine or illegal drug use Alcohol consumption totaling more than 10 standard drinks per week Unable to grant voluntary informed consent Unable or unwilling to follow the study protocol Per the POWERbreathe device user manual: history of spontaneous pneumothorax; a collapsed lung that has not fully healed; a pacemaker or medical implant containing magnets or electronics; any condition of the eardrum, such as a burst eardrum that has not fully healed