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Midday Bright Light Therapy for Bipolar Depression
Sponsor: Istanbul University - Cerrahpasa
Summary
This randomized, double-blind, placebo-controlled study evaluated adjunctive midday bright light therapy in adults with bipolar I or II disorder experiencing mild-to-moderate depression. Participants received either 10,000-lux bright light or 1,500-lux placebo light at home for 30 minutes daily between 12:00 PM and 2:00 PM for four weeks while continuing unchanged pharmacological treatment. The primary outcome was remission at week 4, defined as a total score below 9 on the Structured Interview Guide for the Hamilton Depression Rating Scale-Seasonal Affective Disorder Version. Secondary outcomes included clinical status, psychosocial functioning, sleep quality, circadian characteristics, and adverse effects.
Official title: Midday Bright Light Therapy for Bipolar Depression: A Randomized, Double-Blind, Placebo-Controlled Trial
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
37
Start Date
2021-04-01
Completion Date
2026-06-11
Last Updated
2026-10-13
Healthy Volunteers
No
Conditions
Interventions
Bright Light Therapy
Bright light therapy was administered using a Beurer TL100 daylight therapy lamp (Beurer, Ulm, Germany) set to deliver 10,000 lux. Participants used the device at home for 30 minutes daily between 12:00 PM and 2:00 PM for four weeks, at a distance of 10 cm from the device. Participants were instructed to keep their face turned toward the light box while avoiding direct and continuous gaze at the light source.
Placebo Light Therapy
Placebo light therapy was administered using the same Beurer TL100 daylight therapy lamp (Beurer, Ulm, Germany) set to deliver 1,500 lux. Participants used the device at home for 30 minutes daily between 12:00 PM and 2:00 PM for four weeks, at a distance of 10 cm from the device, following the same instructions as the active treatment group.
Locations (2)
Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine
Istanbul, Turkey (Türkiye)
Bakırköy Prof. Dr. Mazhar Osman Training and Research Hospital for Psychiatry, Neurology and Neurosurgery
Istanbul, Turkey (Türkiye)