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A Research Study to Look at How Well Zenagamtide Works Compared to Placebo in People With Established Atherosclerotic Cardiovascular Disease and Either Overweight or Obesity
Sponsor: Novo Nordisk A/S
Summary
This clinical study is being conducted to evaluate the safety and effectiveness of zenagamtide in people with atherosclerotic cardiovascular disease (ASCVD) and excess body weight compared with placebo. The purpose of this clinical study is to find out if zenagamtide is safe and effective for treating people who have ASCVD and excess body weight. Participants will be randomly assigned by chance to receive either zenagamtide, the investigational treatment being tested, or a placebo, which contains no active medicine. Half of the participants will receive zenagamtide, and treatment assignment will be determined randomly. Zenagamtide is a new investigational medicine that is not yet available for prescription by doctors.
Official title: Zenagamtide Use for the Reduction of Risk of Major Adverse Cardiovascular Events in People With Established Atherosclerotic Cardiovascular Disease and Either Overweight or Obesity
Key Details
Gender
All
Age Range
45 Years - Any
Study Type
INTERVENTIONAL
Enrollment
8500
Start Date
2026-10-26
Completion Date
2030-09-16
Last Updated
2026-10-06
Healthy Volunteers
No
Conditions
Interventions
Zenagamtide
Zenagamtide will be administered subcutaneously.
Placebo
Placebo will be administered subcutaneously.
Locations (769)
Uni of Alabama at Birmingham
Birmingham, Alabama, United States
Eastern Shore Rsrch Inst, LLC
Fairhope, Alabama, United States
Mobile Heart Specialists
Mobile, Alabama, United States
Chambliss Clinical Trials LLC
Montgomery, Alabama, United States
Mercy Gilbert Medical Center
Gilbert, Arizona, United States
Sun City Clinical Research
Glendale, Arizona, United States
Honor Health
Scottsdale, Arizona, United States
Clinical Research Institute of Arizona
Surprise, Arizona, United States
National Heart Institute Cal
Beverly Hills, California, United States
California Inst Of Renal Res
Chula Vista, California, United States
Valley Clinical Trials
Covina, California, United States
First Valley Medical Group
Lancaster, California, United States
Torrance Clin Res Inst, Inc.
Lomita, California, United States
Pacific Clinical Studies
Los Alamitos, California, United States
Academic Medical Research Institute
Los Angeles, California, United States
Valley Clinical Trials, Inc.
Northridge, California, United States
Desert Oasis Hlthcr Med Group
Palm Springs, California, United States
Clinical Trials Research_Sacramento
Sacramento, California, United States
Paradigm Clinical Research
San Diego, California, United States
N America Res Inst - San Dimas
San Dimas, California, United States
Fomat Medical Research
Santa Maria, California, United States
Bridgeport Hospital
Bridgeport, Connecticut, United States
Innovative Research of W FL
Clearwater, Florida, United States
Nature Coast Clin Rsrch_Crystal River
Crystal River, Florida, United States
Florida Premier Cardiology
Delray Beach, Florida, United States
Encore Medical Research LLC
Hollywood, Florida, United States
Est Cst Inst for Rsrch,Jksnvil
Jacksonville, Florida, United States
Jacksonville Ctr Clin Res
Jacksonville, Florida, United States
Clinical Research of Cent FL
Lakeland, Florida, United States
K2 Medical Research
Maitland, Florida, United States
Life Spring Research Foundation LLC
Miami, Florida, United States
Flourish Research - North Miami
Miami, Florida, United States
Oceane 7 Medical & Research Center, Inc.
Miami, Florida, United States
San Marcus Res Clin Miami Lakes
Miami Lakes, Florida, United States
Advance Rsch for Hlth Improvement_Naples
Naples, Florida, United States
Suncoast Clinical Research, Inc.
New Port Richey, Florida, United States
Ocala Cardiovascular Research
Ocala, Florida, United States
Oviedo Medical Research, LLC
Oviedo, Florida, United States
Cardio Partners Clin Res Inst
Palm Beach Gardens, Florida, United States
Suncoast Clinical Research, Inc.
Palm Harbor, Florida, United States
Suncoast Research Associates LLC
Pembroke Pines, Florida, United States
Florida Kidney Physicians LLC
Riverview, Florida, United States
Care Access
Tamarac, Florida, United States
Cardiovascular Associates of America
Wellington, Florida, United States
Javara/Privia Med Grp GA,LLC
Albany, Georgia, United States
West Georgia Cardiology
Carrollton, Georgia, United States
Cardiovascular Care Center & CRC
Conyers, Georgia, United States
Hope Clin Res & Wellness
Conyers, Georgia, United States
Core Clinical Trials
Cordele, Georgia, United States
NSC Research, Inc
Johns Creek, Georgia, United States
GA Arrhythmia Cons & Rsch Inst
Macon, Georgia, United States
Ukpong Cardiology Service
Moultrie, Georgia, United States
Javara Inc. / Privia Medical Group Georgia LLC
Peachtree City, Georgia, United States
Atlanta Heart Specialist
Tucker, Georgia, United States
Rocky Mountain Diab&Osteo Ctr
Idaho Falls, Idaho, United States
Macoupin Research Group
Gillespie, Illinois, United States
Elevate Clinical Research
Gurnee, Illinois, United States
Chicago Medical Research LLC
Hazel Crest, Illinois, United States
Cardiovascular Associates of America
Moline, Illinois, United States
Genesis Orthopedics & Sports Medicine
Oak Brook, Illinois, United States
UnityPoint Health-Diabetes Care Center
Peoria, Illinois, United States
Cardiovascular Associates of America
Schaumburg, Illinois, United States
American Health Network of Indiana, LLC_Avon_0
Avon, Indiana, United States
American Health Network of IN LLC_Franklin
Franklin, Indiana, United States
American Health Network of Indiana, LLC_Greenfield
Greenfield, Indiana, United States
American Health Network of IN LLC
Muncie, Indiana, United States
West Broadway Clinic
Council Bluffs, Iowa, United States
University of Iowa Prev Inter Ctr
Iowa City, Iowa, United States
Iowa Diab & Endo Res Center
West Des Moines, Iowa, United States
Cotton O'Neil Diab & Endo Ctr
Topeka, Kansas, United States
The Research Group of Lexington LLC
Lexington, Kentucky, United States
Norton Clinical Research Group
Louisville, Kentucky, United States
Grace Research, LLC
Bossier City, Louisiana, United States
Louisiana Heart Center
Covington, Louisiana, United States
Louisiana Heart Center_Slidell
Slidell, Louisiana, United States
MedStar Good Samaritan Hosp
Baltimore, Maryland, United States
Ascension Saint Agnes Heart Ca
Baltimore, Maryland, United States
Flourish Research Bowie
Bowie, Maryland, United States
Centennial Medical Group
Columbia, Maryland, United States
Henry Ford Health System
Detroit, Michigan, United States
Elite Research Center
Flint, Michigan, United States
Arcturus Healthcare, PLC.
Troy, Michigan, United States
Trinity Health Michigan Heart
Ypsilanti, Michigan, United States
Clinical Research Professionals
Chesterfield, Missouri, United States
Clinical Research Consultants
Kansas City, Missouri, United States
The Alliance for Multispecialty Research LLC AMR
Kansas City, Missouri, United States
Headlands Research
Springfield, Missouri, United States
Amicis Centers of Clinical Research
St Louis, Missouri, United States
VA NEB - Western IA Health Stm
Omaha, Nebraska, United States
University of Nebraska Medical Center
Omaha, Nebraska, United States
Palm Research Center Inc-Vegas
Las Vegas, Nevada, United States
Seacoast Kidney & Htn Specialists
Portsmouth, New Hampshire, United States
Central New York Clinical Research CNYCR
Manlius, New York, United States
Mid Hudson Med Res-New Windsor
New Windsor, New York, United States
NYU School of Medicine
New York, New York, United States
NYC Health + Hospitals/Lincoln
The Bronx, New York, United States
Great Lakes Medical Research
Westfield, New York, United States
Durham Nephrology Associates
Durham, North Carolina, United States
Medication Mgmnt, LLC_Grnsboro
Greensboro, North Carolina, United States
Carteret Medical Group
Morehead City, North Carolina, United States