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BPPV Recurrence After CRM With & Without Supplementation
Sponsor: University of Jordan
Summary
Benign paroxysmal positional vertigo (BPPV) may frequently recur even after successful canalith repositioning maneuvers (CRMs). This study investigates whether the addition of vitamin K₂ to vitamin D₃ offers additional benefits for reducing recurrence. It involved 404 adults treated at a single otolaryngology center in Amman, Jordan, divided into three groups: combined D3K2 (n = 212), D3 alone (n = 105), and CRM alone (n = 87). The study used modified Poisson regression to analyze 12-month recurrence rates, adjusting for confounding factors. Recurrence was clinically confirmed during the follow-up period.
Official title: Benign Paroxysmal Positional Vertigo Recurrence After Canalith Re-positioning: A 12-Month Prospective Cohort Comparison of Vitamin D₃ Plus K₂, Vitamin D₃ Alone, and Maneuver Alone.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
404
Start Date
2025-01-01
Completion Date
2026-08-31
Last Updated
2026-10-06
Healthy Volunteers
No
Conditions
Interventions
Combined vitamin D₃ and K₂ supplementation
All patients who were diagnosed with benign paroxysmal positional vertigo (BPPV) underwent a canalith repositioning maneuver (CRM) and received combined vitamin D₃ and K₂ supplementation. Then they were followed for 12 months, during which recurrent attacks of BPPV were recorded. The combined regimen consisted of cholecalciferol 4000 IU daily and men-aquinone-7 (MK-7) 200 μg daily for 12 months. The MK-7 dose was selected on the basis of prior clinical work showing enhanced carboxylation of vitamin K-dependent proteins.
Vitamin D₃ alone
All patients who were diagnosed with benign paroxysmal positional vertigo (BPPV) underwent a canalith repositioning maneuver (CRM) and received vitamin D₃ only supplementation (4000 IU daily for 12 months). Then they were followed for 12 months, during which recurrent attacks of BPPV were recorded.
Canalith repositioning maneuver (CRM) alone
All patients who were diagnosed with benign paroxysmal positional vertigo (BPPV) underwent a canalith repositioning maneuver (CRM)
Locations (1)
University of Jordan
Amman, Jordan