Clinical Research Directory

Inclusion Criteria: * Age ≥55 years * Adequate hearing and visual acuity to participate in the examinations (with or without aids) * Ability to read and write in English * Competence to provide informed consent * Montreal Cognitive Assessment score ≥26 * Stable medications for ≥3 months Exclusion Criteria: * Vision or hearing impairment that would impair the ability to complete study assessments * Active CNS disease including multiple sclerosis, uncontrolled seizures, active brain cancer * Cerebrovascular accident other than TIA within 60 days prior to Visit 0 * Major psychiatric disease, including major depression not currently controlled and alcohol or drug abuse * Abnormal kidney function (creatinine \>2mg/dL or EGFR \<30mL/min) by most recent labs within 6 months prior to Visit 0 * Elevated liver enzymes (AST and/or ALT above x2 upper limit of normal) by most recent labs within 6 months prior to Visit 0 * Elevated blood calcium level (above 10.3 mg/dL) by most recent labs within 6 months prior to Visit 0 * History of kidney stones * Any other medical condition which, in the opinion of investigator, would render the patient inappropriate or too unstable to complete the study protocol * Current use of AKG or NAD+ supplements