Clinical Research Directory
Browse clinical research sites, groups, and studies.
Long-Term Recovery and Quality of Life in Sepsis Survivors
Sponsor: University of Geneva, Switzerland
Summary
The goal of this observational study is to learn about the long-term outcomes and recovery of adult patients admitted to the intensive care unit (ICU) with sepsis. The main questions it aims to answer are: * Which patient-related, infection-related and centre-level factors (for example type of pathogen, time to adequate antibiotic therapy, and local sepsis management practices) are associated with poor quality of life six months after ICU admission for sepsis? * How do these factors influence other patient-centred outcomes, such as mortality, psychological and cognitive recovery, functional status and return to work? This is an international, multicentre, prospective observational cohort study. It will consecutively enrol adult patients (18 years or older) admitted to participating ICUs with sepsis, diagnosed by the treating clinician at ICU admission and, where locally available, meeting Sepsis-3 criteria. Participants will: * have clinical data collected from their medical records at ICU admission, on day 7 and at ICU discharge (infection characteristics, organ support, antibiotic therapy, delirium, rehabilitation and centre organisation); * be followed at 28 days (medical record review, or telephone contact if already discharged) and contacted by telephone at 3 months and 6 months after ICU admission for structured assessment of quality of life, psychological and cognitive recovery, functional status, return to work and healthcare utilisation. The study plans to enrol 600 patients in participating ICUs across several countries, coordinated by Geneva University Hospitals (HUG). Findings will help identify modifiable factors that may improve long-term recovery and guide future interventions for sepsis survivors.
Official title: The UNCOVER Study: From ICU to Long-Term Recovery - An International Cohort Study on Risk Factors, Trajectories, and Quality of Life in Sepsis Survivors
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
530
Start Date
2026-09-01
Completion Date
2028-09-01
Last Updated
2026-10-07
Healthy Volunteers
No
Interventions
Care for Sepsis
Participants will receive standard clinical care for sepsis according to local hospital protocols. This study is purely observational: no experimental drugs, procedures, or behavioral interventions are introduced. Data will be collected prospectively on infection characteristics, timing of adequate antibiotic therapy, organ support, and rehabilitation practices during the ICU stay. Follow-up at 28 days, 3 months, and 6 months will assess patient-centered outcomes such as quality of life (EQ-5D-5L), cognitive and mental health status, and return to work. All treatments and decisions remain under the responsibility of the attending medical team.
Locations (1)
Hopitaux Universitaires de Geneve (HUG)
Geneva, Switzerland