Clinical Research Directory

Inclusion Criteria: 1. Adults with HHT who need regular intravenous iron or blood transfusions. 2. Females of childbearing potential and male participants must agree to comply with the contraception requirements. 3. Able to understand and is willing and able to comply with the study requirements and study procedures and agrees to participate in the study by giving written informed consent. Exclusion Criteria: 1. History of anemia of any cause other than HHT-related bleeding, or any other clinically significant inherited bleeding disorder aside from HHT. 2. Has undergone or is anticipated to undergo liver transplantation. 3. Medical conditions or comorbidities that, in the opinion of the investigator, would interfere with study compliance or data interpretation; or, in the opinion of the Investigator, taking part in the study would jeopardize the safety of the patient. 4. History of hemorrhage from untreated pulmonary arteriovenous malformations (AVMs) manifesting as hemoptysis or hemothorax within 12 weeks before screening. 5. Receipt of any vaccination within 2 weeks prior to first dose. 6. Recent major surgery (within 4 weeks before the screening visit) or planned major surgery during the study. 7. GI bleeding due to non-HHT disease (e.g., GI ulcers, diverticulosis), in the opinion of the investigator, within 6 months before screening.