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CO₂ Laser With or Without Platelet-Rich Plasma for Genitourinary Syndrome of Menopause
Sponsor: National and Kapodistrian University of Athens
Summary
This study evaluated whether adding platelet-rich plasma (PRP) to fractional CO₂ laser treatment provides additional benefit for postmenopausal women with genitourinary syndrome of menopause (GSM). Participants received either fractional CO₂ laser treatment alone or fractional CO₂ laser combined with PRP injections. Both groups received three treatment sessions at 4-6-week intervals. The main outcome was the change in vaginal dryness after treatment. Other outcomes included vaginal symptoms, sexual function, quality of life, and measures of vaginal health. The study also evaluated the safety and tolerability of both treatments.
Official title: Fractional CO₂ Laser Versus Combined CO₂ Laser and Platelet-Rich Plasma for the Management of Genitourinary Syndrome of Menopause: A Prospective Study.
Key Details
Gender
FEMALE
Age Range
45 Years - Any
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2023-06-01
Completion Date
2025-04-01
Last Updated
2026-10-08
Healthy Volunteers
No
Interventions
Fractional CO₂ Laser
Fractional laser treatment was performed using the DEKA DUOGlide GYN system (DEKA M.E.L.A., Florence, Italy), combining CO₂ (10,600 nm) and 1540 nm wavelengths. Three treatment sessions were performed at 4-6-week intervals.
Autologous Platelet-Rich Plasma (PRP)
Autologous PRP was prepared from 40 mL of peripheral blood using the OMNIPLEX Gyno kit, yielding approximately 3 mL of PRP with a platelet concentration approximately nine times baseline. PRP was injected into predefined vaginal sites immediately after each laser treatment.
Locations (1)
Alexandra General Hospital
Athens, Greece