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Basal LH Threshold for the Diagnosis of Central Precocious Puberty
Sponsor: University Hospital, Strasbourg, France
Summary
This retrospective monocentric observational study aims to evaluate whether basal luteinizing hormone (LH) levels can reliably diagnose central precocious puberty and reduce the need for LHRH stimulation testing. Currently, all patients with suspected precocious puberty undergo LHRH testing regardless of basal LH levels. The study will analyze pediatric patients evaluated between 2019 and 2024 to determine an optimal basal LH threshold with high specificity. Secondary analyses will assess diagnostic performance and explore clinical and biological factors influencing LH levels. The results may help reduce unnecessary testing and improve diagnostic strategies.
Official title: Can LHRH Stimulation Testing Be Avoided? Evaluation of a Basal LH Threshold in Central Precocious Puberty
Key Details
Gender
All
Age Range
4 Years - 11 Years
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2026-03-02
Completion Date
2027-01-02
Last Updated
2026-10-07
Healthy Volunteers
No
Conditions
Locations (1)
Service de Pédiatrie 1 - CHU de Strasbourg - France
Strasbourg, France