Clinical Research Directory

First-Trimester Screening of Open Neural Tube Defects Using Biometrics and Maternal Serum Markers

Sponsor: University Hospital, Strasbourg, France

Summary

Open neural tube defects are congenital malformations associated with significant morbidity. Early detection during the first trimester remains a key challenge. This retrospective monocentric study aims to evaluate the diagnostic performance of fetal biometrics (biparietal diameter and abdominal transverse diameter ratios) and maternal serum markers (beta-hCG and PAPP-A) for early screening of open neural tube defects. The study will assess the predictive value of these parameters individually and in combination to define optimal screening thresholds applicable in routine clinical practice

Official title: Analysis of Fetal Biometrics and Maternal Serum Markers in First-Trimester Screening of Open Neural Tube Defects

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