Clinical Research Directory
Browse clinical research sites, groups, and studies.
Opioid-Free Versus Opioid-Based Anesthesia in Thyroid Surgery
Sponsor: Malatya Egitim Ve Arastirma Hastanesi
Summary
This study will compare opioid-free anesthesia and opioid-based anesthesia in adult euthyroid patients undergoing elective thyroidectomy. Opioid-based anesthesia is commonly used during surgery, but opioids may be associated with adverse effects such as nausea, vomiting, respiratory depression, hyperalgesia, and increased postoperative opioid use. Opioid-free anesthesia uses non-opioid medications as part of a multimodal strategy to provide intraoperative analgesia. The main aim of this prospective randomized study is to evaluate whether opioid-free anesthesia changes the perioperative oxidative stress response compared with opioid-based anesthesia. Oxidative stress will be assessed using serum biomarkers, including native thiol, total thiol, disulfide, total antioxidant status, total oxidant status, and oxidative stress index. Eligible patients will be randomly assigned to receive either opioid-free anesthesia or fentanyl-based opioid anesthesia. Blood samples will be collected before anesthesia induction, 30 minutes after extubation, and 24 hours after surgery. The study will also compare postoperative pain scores, rescue analgesic requirement, postoperative nausea and vomiting, recovery characteristics, and intraoperative hemodynamic variables between the two anesthesia strategies.
Official title: Effects of Opioid-Free and Opioid-Based Anesthesia on Perioperative Oxidative Stress Biomarkers in Euthyroid Adult Patients Undergoing Elective Thyroidectomy: A Prospective Clinical Trial
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
110
Start Date
2026-04-01
Completion Date
2027-03-31
Last Updated
2026-10-07
Healthy Volunteers
Yes
Conditions
Interventions
Fentanyl (IV)
Fentanyl-based intraoperative analgesia consisting of fentanyl 1-2 mcg/kg intravenously at induction followed by fentanyl infusion at 1-2 mcg/kg/hour during surgery. No additional fentanyl bolus will be administered, and the total intraoperative fentanyl dose will not exceed 5 mcg/kg.
Dexmedetomidine and lidocaine
Dexmedetomidine will be administered intravenously at 0.4-0.7 mcg/kg/hour without a loading dose. The infusion will be discontinued 10-15 minutes before the end of surgery. Intravenous lidocaine will be administered as a 1-1.5 mg/kg bolus followed by a continuous infusion of 1-2 mg/kg/hour during surgery. The lidocaine infusion will be discontinued at the end of surgery.
Locations (1)
Malatya Turgut Ozal University Faculty of Medicine, Malatya Training and Research Hospital
Malatya, Turkey (Türkiye)