Clinical Research Directory
Browse clinical research sites, groups, and studies.
High-Flow Tracheal Oxygen During Spontaneous Breathing Trial
Sponsor: Argentinian Intensive Care Society
Summary
The purpose of this study is to find out whether high-flow tracheal oxygen (HFTO) delivered at flows greater than 60 L/min can increase end-expiratory lung volume (EELV) in intubated patients during a spontaneous breathing trial (SBT). Weaning from mechanical ventilation can be difficult, especially in patients at higher risk of failure. During an SBT, losing positive end-expiratory pressure (PEEP) can cause the lungs to lose volume and make breathing harder by increasing the work of breathing (WOB). HFTO may help reduce the work of breathing, but previous studies using flows of 30-60 L/min did not consistently show an increase in EELV. Higher flows may create more airway pressure. Therefore, the main question this study is trying to answer is: In intubated patients during an SBT, does HFTO at flows greater than 60 L/min increase EELV? The hypothesis is that HFTO at flows above 60 L/min will increase EELV during the SBT.
Official title: Effect of High-flow Tracheal Oxygen on End-expiratory Lung Impedance and Work of Breathing in Intubated Patients During a Spontaneous Breathing Trial.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2026-10-01
Completion Date
2027-03-31
Last Updated
2026-10-07
Healthy Volunteers
No
Interventions
T-piece, HFTO 50, washout, HFTO 70, washout, PSV.
Participants randomized to this Sequence receive the following conditions during a spontaneous breathing trial (SBT): T-piece (baseline) - 15 minutes High-flow tracheal oxygen (HFTO) at 50 L/min - 15 minutes Washout on T-piece - 15 minutes HFTO at 70 L/min - 15 minutes Washout on T-piece - 15 minutes Pressure support ventilation (PSV) 7 cmH₂O / PEEP 0 cmH₂O - 15 minutes Throughout the sequence, end-expiratory lung impedance (EELI), work of breathing (esophageal pressure-derived parameters), respiratory rate, SpO₂, hemodynamic variables, dyspnea, and diaphragmatic thickening fraction (DTF) are measured. This is one of two randomized crossover sequences; all participants receive all conditions in the order assigned by randomization.
T-piece, HFTO 70, washout, HFTO 50, washout, PSV.
Participants randomized to this Sequence receive the following conditions during a spontaneous breathing trial (SBT): T-piece (baseline) - 15 minutes High-flow tracheal oxygen (HFTO) at 70 L/min - 15 minutes Washout on T-piece - 15 minutes HFTO at 50 L/min - 15 minutes Washout on T-piece - 15 minutes Pressure support ventilation (PSV) 7 cmH₂O / PEEP 0 cmH₂O - 15 minutes Throughout the sequence, end-expiratory lung impedance (EELI), work of breathing (esophageal pressure-derived parameters: ΔPes, PTPes, PTPes-min), respiratory rate, SpO₂, hemodynamic variables, dyspnea, and diaphragmatic thickening fraction (DTF) are measured. This is one of two randomized crossover sequences; all participants receive all conditions in the order assigned by randomization.