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Low-dose Imaging TechniquE in Breast MRI
Sponsor: Manojkumar Saranathan
Summary
The purpose of the study is to compare a low-dose contrast enhanced breast MRI (bMRI) protocol with a standard dose protocol, using a dual-dose injection technique. By assessing the conspicuity and enhancement of lesions detected during bMRI, the investigators hope to demonstrate that lower doses of contrast agent may be clinically feasible.
Official title: Low-dose Imaging TechniquE in Breast MRI: LITE bMRI
Key Details
Gender
FEMALE
Age Range
30 Years - 89 Years
Study Type
INTERVENTIONAL
Enrollment
300
Start Date
2026-11-01
Completion Date
2029-01-01
Last Updated
2026-10-07
Healthy Volunteers
No
Conditions
Interventions
Standard of care contrast agent, provided in split dose
Total dosage of the contrast agent provided is the same as for a clinically indicated standard of care breast MRI. To evaluate the low-dose images and compare them to standard dose images, we will deliver the contrast agent in two sequential administrations. First, a small fraction of the standard dose of contrast agent will be administered. Approximately 10 minutes after the first injection, the remaining dose (i.e. full dose -the low dose amount) of the standard contrast will be administered.
Breast MRI
A standard of care breast MRI will be performed. One additional set of sequences will be captured, after the first portion of the split dose is administered.
Locations (1)
UMass Chan Medical School
Worcester, Massachusetts, United States