Clinical Research Directory
Browse clinical research sites, groups, and studies.
Impact of Dietary Flavanols on Microvascular Function in Young Females During Mental Stress
Sponsor: University of Birmingham
Summary
The aim of this project is to examine whether flavonoids, which are small molecules naturally present in cocoa, as well as fruits and vegetables such as berries, tea, citrus fruits, apple (typically responsible for giving these foods their strong colours), can be used to protect the human vascular system. Impaired vascular function, as determined by measuring vasodilator responses to various everyday stimuli, can be linked to elevated blood pressure (hypertension) and prevalence of cardiovascular disease. Vascular response to mental stress in particular have been shown to be associated with future risk of cardiovascular disease. Findings from this study could have implications for effective prevention of cardiovascular events in groups with increased cardiovascular risk, such as South Asians and in particular, South Asian women.
Official title: Acute Effects of Dietary Flavanols on Microvascular Responses to Mental Stress in White European and South Asian Women: A Randomised, Placebo-controlled, Double-blind, Cross-over Preliminary Intervention Study
Key Details
Gender
FEMALE
Age Range
18 Years - 26 Years
Study Type
INTERVENTIONAL
Enrollment
23
Start Date
2020-02-07
Completion Date
2023-02-23
Last Updated
2026-10-07
Healthy Volunteers
Yes
Conditions
Interventions
High-flavanol cocoa powder
12 g of fat-reduced natural cocoa powder containing 695 mg of total flavanols, including 150 mg (-)-epicatechin
Low-flavanol cocoa powder
12 g of fat-reduced alkalized cocoa powder containing 5.6 mg of total flavanols
Locations (1)
School of Sport, Exercise & Rehabilitation Sciences
Birmingham, West Midlands, United Kingdom