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Vaginal Lactobacillus for Postoperative Microecology and Mucosal Repair in MRKH Syndrome
Sponsor: Obstetrics & Gynecology Hospital of Fudan University
Summary
This study is aimed to evaluate the promoting effects of vaginal Lactobacillus capsule on microecological reconstruction and mucosal repair of the neovagina after biological graft vaginoplasty in patients with MRKH syndrome, , through a randomized controlled trial (RCT).
Official title: Effects of Vaginal Lactobacillus Capsule on Postoperative Vaginal Microecology and Mucosal Repair in Patients With Mayer-Rokitansky-Küster-Hauser (MRKH) Syndrome
Key Details
Gender
FEMALE
Age Range
18 Years - 35 Years
Study Type
INTERVENTIONAL
Enrollment
32
Start Date
2026-11-01
Completion Date
2028-06-30
Last Updated
2026-10-08
Healthy Volunteers
No
Conditions
Interventions
postoperative application of vaginal Lactobacillus capsule
The patients in intervention group (n=16) will wash the vulva with clean water every night and then insert one Dingjunsheng capsule (0.25 g/capsule, containing Lactobacillus delbrueckii ≥0.25 × 10⁶ CFU/mL; for vaginal use; Lot No.: 20120804; Inner Mongolia Shuangqi Pharmaceutical Co., Ltd.) deep into the vagina once nightly for 10 consecutive days. The methods of disinfecting and wearing the vaginal mold will be the same in both groups.
routine care
The patients in control group (n=16) will wash the vulva with clean water every night without using any medication and wear the vaginal mold. The methods of disinfecting and wearing the vaginal mold will be the same in both groups.