Clinical Research Directory

Inclusion Criteria: * \- Age 18 years or older * Clinical diagnosis of thyroid eye disease with stable thyroid function for at least 3 months * Unilateral or bilateral upper eyelid retraction with Margin Reflex Distance 1 greater than 4.5 mm in at least one eye * Thyroid eye disease duration less than 24 months * Written informed consent Exclusion Criteria: * \- Active sight-threatening thyroid eye disease requiring urgent decompression or systemic immunosuppression * Current or recent (within 3 months) systemic corticosteroids or other immunosuppressives for thyroid eye disease * Previous levator or Müller muscle surgery, botulinum toxin, or filler injection to the upper eyelid within 6 months * Contraindications to local steroid injection (active ocular infection, uncontrolled glaucoma, pregnancy or lactation) * Significant corneal exposure keratopathy requiring immediate surgical intervention