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Medical Management vs Partial Revascularization in Diffuse Multivessel Coronary Artery Disease
Sponsor: CH. Pervaiz Elahi Institute of Cardiology, Multan
Summary
This randomized controlled trial will compare the clinical outcomes of partial revascularization with percutaneous coronary intervention (PCI) versus optimal medical therapy (OMT) alone in patients with diffuse multivessel coronary artery disease who are not suitable for complete surgical or percutaneous revascularization. A total of 140 eligible patients will be randomized into two groups. The partial revascularization group will undergo PCI of the left anterior descending artery, while the control group will receive guideline-directed optimal medical therapy. Patients will be followed for 12 months, with major adverse cardiovascular events (MACE) and Canadian Cardiovascular Society (CCS) angina class assessed at 3, 6, and 12 months.
Official title: Comparison of Clinical Outcome of Medical Management vs Partial Revascularization in Patients of Multivessel Diffuse Coronary Artery Disease Not Suitable for CABG: A Randomized Controlled Trial.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
140
Start Date
2025-07-16
Completion Date
2027-01-15
Last Updated
2026-10-08
Healthy Volunteers
No
Conditions
Interventions
Partial per cutaneous coronary intervention
PCI of the left anterior descending artery in patients with diffuse multi vessel coronary artery disease who are not suitable for complete Revascularization
Optimal medical therapy (OMT)
Patients managed conservatively with guideline directed medical therapy.
Locations (1)
CPEIC, Multan, Pakistan
Multan, Punjab Province, Pakistan