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Nano-Silver Versus Bioactive Glass for Primary Teeth Exposed to Therapeutic Radiation
Sponsor: Faculty of Dental Medicine for Girls
Summary
This study aims to evaluate and compare the remineralizing and antimicrobial effects of nano silver fluoride and bioactive glass gel on primary teeth exposed to therapeutic radiation. The study includes both in vitro and in vivo components. The clinical component will include 30 pediatric patients aged 6-10 years undergoing therapeutic head and neck radiotherapy. Participants will be randomly allocated into two groups to receive either nano silver fluoride or bioactive glass gel. The effects of the interventions will be evaluated using salivary pH and bacterial count measurements. The laboratory component will evaluate changes in irradiated primary tooth enamel, including surface morphology, mineral content, and microhardness.
Official title: Antimicrobial and Remineralization Efficacy of Nano-Silver Versus Bioactive Glass on Primary Teeth Exposed to Therapeutic Radiation
Key Details
Gender
All
Age Range
6 Years - 10 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2026-07-11
Completion Date
2027-02-15
Last Updated
2026-10-08
Healthy Volunteers
No
Conditions
Interventions
Nano Silver Fluoride
Nano silver fluoride solution will be topically applied once for 1 minute
Bioactive Glass Gel
Bioactive glass gel will be topically applied once daily for 1 minute for 7 consecutive days
Locations (1)
National Cancer Institute, Cairo University
Cairo, Cairo Governorate, Egypt