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AKI and Delirium Risk Prediction and Cost Burden Study
Sponsor: University of Nebraska
Summary
The goal of this study is to learn how to better predict two common health problems that can happen during a hospital stay: acute kidney injury (AKI) and delirium. AKI is a sudden decline in kidney function. Delirium is a sudden change in thinking or awareness that can cause confusion. Both conditions can make people stay in the hospital longer and may increase health care costs. The two main questions this study aims to answer are: 1. How do hospital acquired AKI and delirium affect how long people stay in the hospital and the cost of their care? 2. Can early information from a patient's electronic health record help researchers predict who may develop AKI or delirium during a hospital stay? Researchers will review information already collected in the electronic health records of adults who were admitted to the hospital. They will look at details such as age, health conditions, laboratory results, nursing and ancillary flowsheets, medications, and vital signs recorded during the first day of hospitalization. Researchers will use this information to build a computer model that estimates a patient's risk of developing AKI or delirium later during the hospital stay. They will also study how these complications affect the length of the hospital stay and the cost of care. This study will not change the care patients receive. Researchers will only use existing medical record data. The results may help doctors identify patients at higher risk earlier and guide steps that may prevent these complications in the future.
Official title: Hospital-Acquired Acute Kidney Injury and Delirium Risk Prediction and Cost Burden
Key Details
Gender
All
Age Range
19 Years - Any
Study Type
OBSERVATIONAL
Enrollment
25000
Start Date
2026-09-01
Completion Date
2027-09-28
Last Updated
2026-10-08
Healthy Volunteers
No
Conditions
Interventions
It is observational trial with no intervention being evaluated
Hospital-acquired acute kidney injury and hospital-acquired delirium will be identified retrospectively from electronic health record data using prespecified clinical definitions. Acute kidney injury will be defined using KDIGO-based criteria, and delirium will be identified using a prespecified phenotype incorporating available CAM-family assessments and other time-stamped structured clinical documentation and flowsheets. Patients with the relevant condition present on admission will be excluded from that outcome analysis. Neither exposure is assigned by the investigators; each will be analyzed separately as a time-varying complication according to its documented onset.
Locations (1)
Nebraska Medical Center
Omaha, Nebraska, United States